Clinical Correlation of Oral Manifestations In HIV Seropositive Patients With CD4+ Cell, CD8+Cell Counts And CD4+/CD8+ Ratio

The Aim of this study was to investigate the correlation of oral lesions in HIV positive patients with their CD4, CD8 cell count and CD4/CD8 ratio. 150 HIV seropositive patients of any age and sex were evaluated. Then analyses of data obtained were revealed Pseudo membranous candidiasis (P-0.0043) was the most common variant, mostly seen when CD8 count was increased (>500 cells/mm, P-0.05) and CD4/CD8 ratio was > 0.31(P-0.0034). Periodontal diseases (29%) mostly were seen in patients with CD4 count >400 cell/ mm (P-0.045), CD8 count >500 CD8 cell/mm (P-0.55) and CD4/CD8 ratio < 0.3(P-0.28). Oral lesions were seen when CD8 count is increased >500 cells/mm and CD4/CD8 ratio is in between 0.31 0.6. Oral lesions especially oral candidiasis can be useful as a diagnostic marker for immunosuppression in HIV positive patients, particularly where laboratory assessment cannot be done routinely.